Harmonization of FT-ICR-MS Instruments for Interoperable Multi-Laboratory Comprehensive Compositional Profiling.

ABSTRACT: Given the long hardware lifespan, fixed installation, and comparatively high investment required to procure them, Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) instruments tend to have a long operational life. The field is constantly evolving with rapidly advancing instrumental developments, and FT-ICR research groups work with a range of instrument designs from different generations. Consequently, compositional spectra comparability between instruments is a critical concern in FT-ICR-MS, particularly due to the variability introduced by commonly used direct infusion methods. This study demonstrates interlaboratory comparability of FT-ICR-MS molecular profiles using a 12 T solariX with an Infinity Cell and a 7 T scimaX with a ParaCell, with closely matched sample

SUBMITTER: Pieczonka SA 

PROVIDER: S-EPMC12019771 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature