The venom of <i>Cyriopagopus schmidti</i> spider contains a natural huwentoxin-IV analogue with unexpected improved analgesic potential.

ABSTRACT: The venom of Cyriopagopus schmidti spider has been extensively investigated, thereby allowing the identification of numerous new natural peptides. Many of these peptides are active on ion channels and several of them occur from post-translational processing. In order to further identify new entities, we screened this venom against five different human voltage-gated sodium (hNa_v) channels. We illustrate the unusual richness of this venom in targeting this wide variety of hNa_v channels. We confirm the identity of previously discovered peptides active on these ion channels type (huwentoxin (HwTx)-I, HwTx-II and HwTx-IV), indicating the efficacy of the screening process by automated patch-clamp. We also identified a novel analogue of HwTx-IV that differs by the abs

SUBMITTER: Antunes A 

PROVIDER: S-EPMC12019880 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature