Repetitive Head Impacts and Perivascular Space Volume in Former American Football Players.

ABSTRACT:

Importance

Exposure to repetitive head impacts (RHI) is associated with increased risk for neurodegeneration. Accumulation of toxic proteins due to impaired brain clearance is suspected to play a role.

Objective

To investigate whether perivascular space (PVS) volume is associated with lifetime exposure to RHI in individuals at risk for RHI-associated neurodegeneration.

Design, setting, and participants

This cross-sectional study was part of the Diagnostics, Imaging, and Genetics Network for the Objective Study and Evaluation of Chronic Traumatic Encephalopathy (DIAGNOSE CTE) Research Project, a 7-year multicenter study consisting of 4 US study sites. Data were collected from September 2016 to February 2020 and analyses were performed between May 2021 and October 2023.

SUBMITTER: Jung LB 

PROVIDER: S-EPMC12025916 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature