N-Acetylcysteine as a Host-Directed Therapy Against Clarithromycin-Resistant <i>Mycobacterium abscessus</i>.

ABSTRACT: (1) Background: The treatment of Mycobacterium abscessus (M. abscessus) infections resistant to clarithromycin (CLR) is highly challenging. Traditional non-tuberculous mycobacteria (NTM) chemotherapy may disturb the immune homeostasis of the host by increasing oxidative stress; therefore, host-directed immunotherapy is an alternative option for infections caused by M. abscessus. (2) Method: A clinical isolate of CLR-resistant M. abscessus was screened, and then the therapeutic effects of N-acetylcysteine (NAC) against CLR-resistant M. abscessus infection were evaluated in Tohoku Hospital Pediatrics-1 (THP-1) cells and murine models. RNA sequencing and Western blot were used to profile the protective immune responses induced by NAC. The contribution of can

SUBMITTER: Yang S 

PROVIDER: S-EPMC12030110 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature