Obesity accelerates age-related memory deficits and alters white matter tract integrity in Ldlr-/-.Leiden mice.

ABSTRACT:

Background

Obesity in mid-adulthood has been suggested to promote brain aging and is associated with progressive cognitive impairment later in life. However, the structural and functional alterations that underlie obesity-related cognitive dysfunction are still poorly understood, partly owing to the lack of translational models replicating age- and obesity-related brain pathology.

Methods

The effect of age and high-fat diet (HFD)-induced obesity was investigated in adult Ldlr-/-.Leiden mice, an established translational model for obesity and its comorbidities. During mid-adulthood, from three to eight months of age, brain structure and function (hippocampal volume, cortical thickness, white matter integrity, cerebral blood flow (CBF), resting-state functional connectivity) w

SUBMITTER: Seidel F 

PROVIDER: S-EPMC12032874 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature