Eradicating <i>Helicobacter pylori</i> via ¹³C-urea breath screening to prevent gastric cancer in indigenous communities: a population-based study and development of a family index-case method.

ABSTRACT:

Objective

Screening and eradication of Helicobacter pylori help reduce disparities in the incidence of gastric cancer. We aimed to evaluate its acceptability and feasibility in the indigenous communities and develop a family index-case method to roll out this programme.

Design

We enrolled residents aged 20-60 years from Taiwanese indigenous communities to receive a course of test, treat, retest and re-treat initial treatment failures with the ¹³C-urea breath tests and four-drug antibiotic treatments. We also invited the family members of a participant (constituting an index case) to join the programme and evaluated whether the infection rate would be higher in the positive index cases.

Results

Between 24 September 2018 and 31 December 2021, 15 057 pa

SUBMITTER: Lei WY 

PROVIDER: S-EPMC12056587 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature