The rs243865 Polymorphism in Matrix Metalloproteinase-2 and its Association With Target Organ Damage in Patients With Resistant Hypertension: Cross-Sectional Study.

ABSTRACT:

Background

Resistant hypertension (RH) presents significant clinical challenges, often precipitating a spectrum of cardiovascular complications. Particular attention recently has focused on the role of matrix metalloproteinase-2 (MMP-2) gene polymorphisms, implicated in hypertensive target organ damage (TOD). Despite growing interest, the specific contribution of MMP-2 polymorphisms to such damage in RH remains inadequately defined.

Objective

This study is the first to examine the rs243865 (-1306C>T) polymorphism in the MMP-2 gene in the Vietnamese population and patients with RH, underscoring its critical role as a genetic determinant of TOD.

Methods

A cross-sectional study with both descriptive and analytical components was conducted with 78 patients with RH at the

SUBMITTER: Tuan Huynh A 

PROVIDER: S-EPMC12061201 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature