Parent-of-origin effects in the life-course evolution of cardiometabolic traits.

ABSTRACT:

Aims/hypothesis

Cardiometabolic traits are heritable, and some display parent-of-origin effects, which indicates preferential inheritance from one parent or parental bias. Most studies of these phenomena have focused on adult populations. We aimed to investigate the heritability and parent-of-origin effects on cardiometabolic traits in a birth cohort with serial measurements to determine whether these patterns emerged early in life.

Methods

The Pune Maternal Nutrition Study comprises a birth cohort in which offspring and parents were studied from birth and followed up for 24 years. We investigated parent-of-origin effects on cardiometabolic traits cross-sectionally at available timepoints using linear regression, and longitudinally across the life course using mixed-effect r

SUBMITTER: Wagh R 

PROVIDER: S-EPMC12069499 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature