White Matter Abnormalities and Cognition in Aging and Alzheimer Disease.

ABSTRACT:

Importance

There has yet to be a large-scale study quantifying the association between white matter microstructure and cognitive performance and decline in aging and Alzheimer disease (AD).

Objective

To investigate the associations between tract-specific white matter microstructure and cognitive performance and decline in aging and AD-related cognitive impairment.

Design setting and participants

This prognostic study of aging and AD, a secondary data analysis of multisite cohort studies, acquired data from 9 cohorts between September 2002 and November 2022. Participants were eligible if they had diffusion-weighted magnetic resonance imaging (dMRI) data, domain-specific cognitive composite z scores, demographic and clinical data, were aged 50 years or older, and

SUBMITTER: Peter C 

PROVIDER: S-EPMC12150229 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature