Robust Assessment of Homologous Recombination Deficiency Genomic Instability by OncoScan Microarrays.

ABSTRACT: Genomic instability scars are markers for detecting homologous recombination deficiency (HRD) status in patients with ovarian cancer and predicting the response to poly (ADP-ribose) polymerase inhibitor treatment. Currently, only a few reliable and validated assays are available, with the Myriad myChoice CDx being the most commonly used commercial assay for genomic instability scar score determination. Given the need for a more straightforward, accessible, and reliable method for detecting genomic instability scars methods, in this work, we describe the feasibility of using the microarray OncoScan copy number variant assay and open-source software packages to quantify genomic instability scores, and the development of an open-access online platform for genomic instability score calculation

SUBMITTER: Lara Gutierrez A 

PROVIDER: S-EPMC12163384 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature