Identification of HMOX-1-Targeting Natural Compounds in <i>Camellia nitidissima</i> Chi for NSCLC Therapy: Integrating Bioassay and In Silico Screening Approaches.

ABSTRACT: Background/Objectives:Camellia nitidissima Chi (C. nitidissima), a traditional Chinese "food and medicine homology" plant, has demonstrated potential anti-tumor properties. However, its mechanisms of anti-lung cancer activity via ferroptosis remain unclear. This study aimed to construct an integrated research system of "natural product extraction-purification, bioactivity evaluation, and computational drug screening" to explore the bioactive compounds in C. nitidissima leaves targeting HMOX-1-mediated ferroptosis and their anti-lung cancer mechanisms. Methods: Active fractions were prepared using ethanol extraction combined with polyamide column chromatography. The anti-lung cancer activity was evaluated using the NCI-H1975 cell model. Ferroptosis was ver

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12196505 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature