Thresholds for Contact Allergy to a Rubber Accelerator: TETD-Determined by Serial Dilution Patch Testing and a Simulated Glove-Use Model.

ABSTRACT:

Background

Rubber accelerators found in rubber gloves may cause contact allergy and thus allergic contact dermatitis.

Objectives

To investigate which doses of tetraethylthiuram disulfide (TETD) elicit allergic contact dermatitis by patch testing and in a repeated occluded application test simulating glove use.

Patients and methods

A multicentre study was conducted. Eight patients with contact allergy to TETD and eight controls comprised the study group. Doses of TETD 1% (400 μg/cm²), 0.33% (130 μg/cm²), 0.11% (44 μg/cm²), 0.037% (15 μg/cm²), 0.012% (4.9 μg/cm²), 0.0041% (1.6 μg/cm²) and pure vehicle (petrolatum) were used for the patch test. Doses of TETD 1% (39 μg/cm²), 0.33% (13 μg/cm²

SUBMITTER: Kursawe Larsen C 

PROVIDER: S-EPMC12223932 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature