MiR-23b is a negative regulator of tumor suppressing PTPRG in colorectal cancer.

ABSTRACT: Colorectal cancer (CRC) is among top most common cancers with high mortality rate and major health issue yet to resolve across the globe. miR-23b is an oncogene in many cancers including CRC. The route of involvement of miR-23b in the regulation of CRC is still unclear. Study explored bioregulatory mechanism of miR-23b against CRC involving in vitro and animal model experimentation via experimentation involving ki67 immunohistochemistry, CCK8, EDU, and Transwell cell migration. The bioinformatic studies were employed to predict miR-23b target tumor suppressor PTPRG while the luciferase reporter gene assay was used to find the binding capabilities of miR-23b to the 3'-UTR of PTPRG. The changes in the expression of miR-23b were found in three CRC cell lines including SW480, HT29, and Caco2,

SUBMITTER: Duan H 

PROVIDER: S-EPMC12240168 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature