ATP1A1-Driven Intercellular Contact Between Dental Pulp Stem Cell and Endothelial Cell Enhances Vasculogenic Activity.

ABSTRACT:

Aim

The interaction between dental pulp stem cells (DPSCs) and vascular endothelial cells (ECs) is crucial to the speedy establishment of functional blood circulation within the transplanted pulp tissue. It is a complex process involving direct cell contact and paracrine signalling. The transmembrane domains of α1-Na⁺/K⁺-ATPase (ATP1A1) have been shown to influence tumour angiogenesis. Its role in regulating DPSCs/ECs interaction in vascular formation remains unknown. This study aimed to explore ATP1A1 on DPSCs/ECs communication, vascular network formation, and underlying mechanisms.

Methods

The formation of vessel structures within different culture systems was examined. The expression of pericyte-like markers and Na⁺/K⁺-ATPase-re

SUBMITTER: Zhu M 

PROVIDER: S-EPMC12260422 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature