Associations of internal persistent organic pollutant levels with sex hormones: An analysis by sex and menopausal status in a Spanish cohort.

ABSTRACT: The aim of this study was to investigate associations between human exposure to persistent organic pollutants and sex hormone levels. The study population (n = 253) was a subsample of GraMo adult cohort, recruited in 2003-2004 in two hospitals from Granada, Spain. Exposure was estimated by analyzing samples of adipose tissue (3 organochlorine pesticides and 3 polychlorinated biphenyls) and serum (4 per- and polyfluoroalkyl substances). Data analyses included robust linear regression and weighted quantile sum regression. In men, PFNA (positively) and PCB-138 (negatively) were associated with testosterone. In premenopausal women, OCPs and PCBs were negatively associated with estradiol and SHBG. PFHxS was inversely related to luteinizing hormone. Additionally, PCB-153 and -180 was posi

SUBMITTER: Perez-Diaz C 

PROVIDER: S-EPMC12270682 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature