Effect of Low-Carbohydrate Diets on C-Reactive Protein Level in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

ABSTRACT: Chronic low-grade inflammation is a probable mediator between the quantity of carbohydrate intake and health outcomes. The aim of this systematic review and meta-analysis of randomized clinical trials (RCTs) was to summarize the effects of low carbohydrate diets (LCDs) as compared to control diets on c-reactive protein (CRP) levels in adults. A comprehensive search was conducted in several databases up to February 2024. In total, 60 eligible trials with 5511 adults were included in the meta-analysis. LCDs resulted in an average reduction of 0.18 mg/L in CRP levels compared to control groups (MD = 0.18; 95% CI: 0.032 to 0.03; p = 0.016); however, sensitivity analysis revealed that this significance was dependent on a single study (Abbaspour Rad et al.), with exclusion of which the ef

SUBMITTER: Khodarahmi M 

PROVIDER: S-EPMC12274166 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature