Neutrophil/monocyte-targeted dual-ligands modified liposomes delivering puerarin for ischemia stroke treatment.

ABSTRACT: Extremely low actual biological effect of insoluble small molecule drugs in ischemia region is a pain point and aporia in Ischemia Stroke (IS) therapy, Although there are studies on single, double-ligands modified liposomes or biomimetic exogenous carriers for directly targeting IS so far, but they often have off-target effects due to they were swallowed, degraded directly (instability) and sabotaged without the help of endogenous cell in the systemic circulation. DSPE-PEG₃₄₀₀-PGP (PGP) and DSPE-PEG₃₄₀₀-cRGD (cRGD) were synthesized via michael addition reaction of maleimide (-Mal) with sulfhydryl (-SH), succinimidyl ester (-NHS) with active primary amine group (-NH₂) respectively. The cRGD and PGP were modified on liposomes by thin film hydration method. Op

SUBMITTER: Ling C 

PROVIDER: S-EPMC12281153 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature