Effect of Subthreshold Nanosecond Laser on Loss of OCT Outer Retinal Bands in Age-Related Macular Degeneration: A LEAD Study Report.

ABSTRACT:

Purpose

To evaluate the effect of subthreshold nanosecond laser (SNL) treatment on the rate of loss of the OCT outer retinal bands in intermediate age-related macular degeneration (AMD).

Design

Post hoc analysis of the Laser Intervention in the Early Stages of AMD (LEAD) study.

Participants

A subset of 285 of 292 individuals in the LEAD study with bilateral large drusen without signs of multimodal imaging-defined late AMD at baseline, seen at 1 follow-up visit where neovascular AMD (nAMD) was absent.

Methods

Participants were randomized to receive SNL or sham treatment in 1 study eye at 6-monthly intervals and were reviewed for up to 36 months. OCT scans from all visits without nAMD were automatically segmented to examine between-group differences in the rate o

SUBMITTER: Guymer RH 

PROVIDER: S-EPMC12281169 | biostudies-literature | 2025 Nov-Dec

REPOSITORIES: biostudies-literature