<i>Weissella cibaria</i> suppresses colitis-associated colorectal cancer by modulating the gut microbiota-bile acid-FXR axis.

ABSTRACT: Gut microbiota dysbiosis critically contributes to colitis-associated colorectal cancer (CAC) pathogenesis, positioning microbial modulation as a promising therapeutic strategy. Weissella cibaria (W. cibaria) is an emerging probiotic with potential cancer-inhibiting effects. This study investigates the anti-tumorigenic potential of W. cibaria in an azoxymethane/dextran sulfate sodium-induced CAC murine model. Mice were orally administered W. cibaria every 2 days from the beginning of the model construction until the end of the experiment. The study demonstrated significant changes in the gut microbiota of CAC mice, with a significant increase in the relative abundance of Lactobacillaceae. Supplementation with W. cibaria restored the intestinal barr

SUBMITTER: Hao Q 

PROVIDER: S-EPMC12282153 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature