Influence of HLA mismatch between donors and recipients on postoperative outcomes in cadaveric lung transplantation.

ABSTRACT:

Objectives

Generally, HLA matching between donors and recipients is not performed in lung transplantation (LTx). Therefore, whether HLA mismatch between donors and recipients (D/R mismatch) influences postoperative outcomes after LTx remains uncertain. In this study, we investigated the influence of D/R mismatch on postoperative outcomes after cadaveric LTx (CLT).

Methods

A total of 140 CLT procedures were performed between 2012 and 2020. After excluding 5 recipients with preformed DSA and 1 recipient undergoing re-LTx, 134 recipients were enrolled in this retrospective study. The postoperative outcomes were compared between recipients with higher and lower D/R mismatches.

Results

The median D/R mismatch (A/B/DR loci) was 4.0 (range, 1-6). When dividing these 134 reci

SUBMITTER: Kayawake H 

PROVIDER: S-EPMC12289801 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature