The Role of Gut Microbiota in Insomnia: A Systematic Review of Case-Control Studies.

ABSTRACT:

Background

Insomnia is one of the most prevalent health concerns and has a major impact on human health and quality of life. Increasing evidence indicates the gut microbiota's role in sleep regulation through the gut-brain axis. This systematic review aims to summarise current evidence on the role of gut microbiota alterations in insomnia.

Methods

We searched PubMed, Embase, and Cochrane Library through November 2024 for case-control studies comparing gut microbiota in insomnia subjects and controls. The primary outcome was changes in microbiota diversity and bacteria taxonomy.

Results

We included 15 case-control studies from 14 articles, consisting of 1321 subjects (603 insomnia; 718 controls). Eight studies showed reduced alpha diversity and eleven showed altered be

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12299568 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature