First Report of the L925I kdr Mutation Associated with Pyrethroid Resistance in Genetically Distinct <i>Triatoma dimidiata</i>, Vector of Chagas Disease in Mexico.

ABSTRACT: Triatoma dimidiata is a widely distributed vector of Trypanosoma cruzi in Mexico and Central America, found across a range of habitats from sylvatic to domestic. Vector control has relied heavily on indoor residual spraying with pyrethroids; however, reinfestation and emerging resistance have limited its long-term effectiveness. In this study, we analyzed the genetic diversity and population structure of T. dimidiata from Veracruz, Oaxaca, and Yucatan using mitochondrial markers (cyt b and ND4) and screened for knockdown resistance (kdr)-type mutations in the voltage-gated sodium channel (VGSC) gene. High haplotype diversity and regional differentiation were observed, with most genetic variation occurring between populations. The ND4 marker provided greater resolution

SUBMITTER: Saucedo-Montalvo MC 

PROVIDER: S-EPMC12299954 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature