Arousal threshold modifies the effect of CPAP on executive function among individuals with obstructive sleep apnoea.

ABSTRACT:

Background

Obstructive sleep apnoea (OSA) is associated with neurocognitive dysfunction. However, randomised trials evaluating the effects of continuous positive airway pressure (CPAP) on neurocognition in those without dementia do not show a benefit. We thus aimed to assess whether arousal threshold (ArTH) modifies the effect of CPAP on neurocognitive function.

Methods

We performed a secondary analysis of a randomised, sham-controlled trial (Apnea Positive Pressure Long-term Efficacy Study (APPLES); ClinicalTrials.gov: NCT00051363). ArTH was estimated from polysomnography using a translatable method. Neurocognitive outcomes included the Sustained Working Memory Test-Overall Mid-Day (SWMT-OMD) score (executive function, primary outcome), with the Pathfinder Number Test total

SUBMITTER: Zinchuk AV 

PROVIDER: S-EPMC12301966 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature