Insulator BEAF32 regulates expression of tissue-specific genes and piRNA source loci in Drosophila ovaries.

ABSTRACT:

Background

Insulators are the multifunctional DNA binding proteins that perform architectural functions and regulate gene transcription. Although insulators have a well-established role in genome organization, it is still unclear how insulator proteins affect the control of tissue-specific processes. The Drosophila insulator BEAF32 (Boundary Element-Associated Factor of 32 kD) is a component of chromatin complexes found in open chromatin regions containing promoters of housekeeping genes. BEAF32 knockout impairs oogenesis and female fertility suggesting its specific functions during oogenesis.

Results

To get a better understanding of BEAF32 roles in oogenesis, we first examined its ovarian binding targets and discovered an enrichment of its localization sites in the promoter

SUBMITTER: Kobelyatskaya AA 

PROVIDER: S-EPMC12302907 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature