Intestinal Bacteroides drives glioma progression by regulating CD8+ T cell tumor infiltration.

ABSTRACT:

Background

The intestinal microbiota regulates normal brain physiology and the pathogenesis of several neurological disorders. While prior studies suggested that this operates through immune cells, the underlying mechanisms remain unclear. Leveraging 2 well-characterized murine models of low-grade glioma occurring in the setting of the neurofibromatosis type 1 (NF1) cancer predisposition syndrome, we sought to determine the impact of the gut microbiome on optic glioma progression.

Methods

Neurofibromatosis type 1 (Nf1)-mutant mice genetically engineered to develop optic pathway gliomas (Nf1OPG mice) by 3 months of age were reared under germ-free (GF) conditions, treated with specific cocktails of antibiotics, or given fecal matter transplants (FMTs). Intestinal microbial spe

SUBMITTER: Chatterjee J 

PROVIDER: S-EPMC12309722 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature