Mechanism of Shenyuan Yiqi Huoxue capsule alleviating coronary microvascular dysfunction: network analysis and experimental evidence.

ABSTRACT:

Background

Shenyuan Yiqi Huoxue Capsule (SYYQ) has clinical evidence to improve coronary microvascular dysfunction (CMD) by tonifying qi and removing blood stasis, but the underlying mechanism remains unclear.

Objective

This study aims to explore the mechanism by which SYYQ alleviates CMD through a combination of network analysis and both in vivo and in vitro experiments.

Methods

First, network pharmacology was employed to predict the mechanism of SYYQ on CMD. Building upon the findings of network pharmacology, we conducted in vivo experiment to verify the improvement mechanism of SYYQ in CMD rats using echocardiography, histopathology, serum biochemistry, TUNEL staining, and transmission electron microscopy (TEM). In the context of cell experimen

SUBMITTER: Chen J 

PROVIDER: S-EPMC12358463 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature