A Microneedle-Based Electrochemical Sensor with Multiplex Detection in Physiological Environment and Incorporated in a Portable Device.

ABSTRACT: The number of disorders linked to deficiencies in vital ions, such as calcium (Ca2+) and potassium (K+), has dramatically increased in recent years. Numerous research studies have proposed the development of a sensor for early detection; however, the bulk of these investigations include the time-consuming process of drawing blood samples for testing. To overcome these challenges, this research highlights the development of a novel portable microneedle-based device for the multiplexed detection of Ca2+ and K+, as well as pH, in artificial interstitial fluid (ISF). A passivation layer of ArCare was investigated to improve the stability, reliability, and repeatability of the microneedle sensors, enhancing their sensitivity and accuracy. Microneedle sensors were modified with Poly-(3,4-ethylen

SUBMITTER: Thatte C 

PROVIDER: S-EPMC12368728 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature