Pesticide exposome reveals oxidative stress and immune response disruptions in occupationally exposed women with breast cancer.

ABSTRACT: Rural women are at a higher risk of developing breast cancer, but the molecular mechanisms involved remain poorly understood. This study investigates the impact of chronic pesticide exposure on systemic and tissue-level protein expressions in women diagnosed with breast cancer. Plasma and tumor samples were collected from 215 women diagnosed with breast cancer; among them, 128 patients were occupationally exposed (n = 128) and 87 patients were not occupationally exposed (87) were analyzed for further studies. High-throughput proteomic analyses of plasma revealed distinct protein expression profiles between the groups, primarily associated with inflammation, oxidative stress, and immune deregulation. Validation analysis showed that cytokines such as IL-1β, IL-12, IL-17A, and TNF-α were sign

SUBMITTER: de Morais Valentim JMB 

PROVIDER: S-EPMC12373925 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature