Metabolic reset purification program improves antioxidant balance and gut microbiome in individuals transitioning to a healthier diet.

ABSTRACT: A healthy diet helps transition individuals towards numerous long-term metabolic benefits but is challenging to maintain. Supplementation with additional whole food-based concentrates and herbs may support this shift by enhancing metabolic resilience. This randomized, controlled, crossover study evaluated a 21-day purification program emphasizing plant foods and whole food supplementation on metabolic detoxification, oxidative stress, and gut microbiota composition. Participants followed a plant-based diet for 7 days, with lean proteins introduced from days 8-21. Whole food supplements rich in polyphenols, glucosinolates, and prebiotic fibers were included to support metabolic and gastrointestinal function. The intervention group exhibited 9% (p < 0.0001) reduction in ROS-associated

SUBMITTER: Panda C 

PROVIDER: S-EPMC12376428 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature