Methylprednisolone for Infant Heart Surgery: Subpopulation Analyses of a Randomized Controlled Trial.

ABSTRACT:

Objectives

Evaluate benefits and harms of prophylactic intraoperative methylprednisolone in subpopulations undergoing infant heart surgery.

Design

Subpopulation analyses of The Steroids to Reduce Systemic Inflammation after Infant Heart Surgery (STRESS) trial, a double-blind randomized placebo-controlled trial.

Setting

Twenty-four congenital heart centers.

Patients

Infants (< 1 yr old) undergoing heart surgery with cardiopulmonary bypass. Patients stratified by Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery Congenital Heart Surgery (STAT) mortality category, age, gestational age, and presence of chromosomal or syndromic diagnosis (CSD).

Interventions

Methylprednisolone (30 mg/kg) vs. placebo administered into cardiopulmonar

SUBMITTER: Sunthankar SD 

PROVIDER: S-EPMC12378003 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature