Single-walled carbon nanotubes hitchhike on Ly-6C^hi monocytes for photoacoustic image-guided photothermal shock therapy of metabolic inflammation.

ABSTRACT: Metabolic inflammation (metaflammation) may occur throughout the body and evolve into various metabolic syndromes, so developing a universal approach for diagnosing and treating metaflammation is meaningful. Here, we developed a single-walled carbon nanotube (SWNT)-based photothermal shock therapy (PTST) for photoacoustic image-guided therapy of metaflammation. Mechanistically, SWNTs are specifically taken up by Ly-6C^hi monocytes in peripheral blood and then rerouted to inflamed tissues via Ly-6C^hi monocyte hitchhiking. Due to the accumulation of SWNTs, inflamed tissues can be distinguished by photoacoustic imaging. For treating metaflammation, inflamed tissue gated by photoacoustic imaging is irradiated with near-infrared light and heated to heat shock tempera

SUBMITTER: Peng R 

PROVIDER: S-EPMC12378547 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature