Biliary Injuries Repair Using Copolymeric Scaffold: A Systematic Review and In Vivo Experimental Study.

ABSTRACT: Background: Common bile duct (CBD) treatments are often associated with complications, limiting long-term efficacy. To overcome these issues, polymeric grafts have been suggested as promising alternatives, since they are highly customizable, biocompatible, and may reduce side effects frequency. Methods: A systematic review was conducted, interrogating MEDLINE and Cochrane Library. Next, an in vivo study involved 20 pigs, which underwent a former controlled biliary injury. To repair the defect, a α,β-Poly(N-2-hydroxyethyl)-DL-Aspartamide (PHEA)-Polylactic-acid (PLA)-Polycaprolactone (PCL) scaffold was implanted. The animals were sacrificed at one and three months for gross and histological examinations, to assess tissue integration and healing outcomes. Results: The systematic review highli

SUBMITTER: Buscemi S 

PROVIDER: S-EPMC12387130 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature