Antioxidant Power of Brown Algae: <i>Ascophyllum nodosum</i> and <i>Fucus vesiculosus</i> Extracts Mitigate Oxidative Stress In Vitro and In Vivo.

ABSTRACT: Brown algae such as Ascophyllum nodosum (AN) and Fucus vesiculosus (FV) are gaining considerable attention as functional feed additives due to their health-beneficial properties. This study evaluated the antioxidant potential of AN and FV extracts in intestinal epithelial cells and the in vivo model Caenorhabditis elegans (C. elegans). Aqueous AN and FV extracts were characterized for total phenolic content (TPC), antioxidant capacity (TEAC, FRAP), and phlorotannin composition using LC-HRMS/MS. Antioxidant effects were assessed in vitro, measuring AAPH-induced ROS production in Caco-2 and IPEC-J2 cells via H₂DCF-DA, and in vivo, evaluating the effects of paraquat-induced oxidative stress and AN or FV treatment on worm motility, GST-4::GFP reporter exp

SUBMITTER: Karlsberger L 

PROVIDER: S-EPMC12387151 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature