Myelin Quantification Using Ultrashort Echo Time Magnetization Transfer Ratio in a Mouse Model of Traumatic Brain Injury.

ABSTRACT:

Background and purpose

This study aims to assess the potential of ultrashort echo time imaging-based magnetization transfer ratio (UTE-MTR) in detecting demyelination in mice with mild traumatic brain injury (mTBI) caused by an open-field low-intensity blast (LIB) injury model.

Methods

This study included 30 male C57BL/6 mice, approximately 8 weeks old, sourced from Jackson Laboratories in Bar Harbor, ME, and conducted under institutional guidelines. The mice were divided into the mTBI group (n = 15) and the sham control group (n = 15). All animal experiments followed the approved protocols for the Care and Use of Laboratory Animals and Animal Research. The mTBI group underwent the open-field LIB injury. Behavioral tests were conducted to assess motor activity and anxiety-li

SUBMITTER: Athertya JS 

PROVIDER: S-EPMC12396502 | biostudies-literature | 2025 Jan-Feb

REPOSITORIES: biostudies-literature