Efficacy and Safety of Tenecteplase in Acute Ischemic Stroke: A Meta-Analysis of Randomized Controlled Trials.

ABSTRACT:

Introduction

Acute ischemic stroke (AIS) is the most common type of stroke, with increasing incidence and significant healthcare costs. Tenecteplase (TNK), a modified variant of tissue plasminogen activator (tPA), offers advantages such as a longer half-life and single-bolus administration. This meta-analysis evaluates the safety and efficacy of TNK compared to non-thrombolytic management in AIS to guide clinical decision-making.

Methodology

A comprehensive literature search across major databases identified randomized controlled trials (RCTs) comparing tenecteplase with non-thrombolytic care in ischemic stroke. Data extraction and bias assessment were conducted independently, using RoB 2.0 and the GRADE framework. Meta-analysis was performed using RevMan 5.4.1, applying ran

SUBMITTER: Bacha Z 

PROVIDER: S-EPMC12402402 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature