Genetic variation in the FMO and GSTO gene clusters impacts arsenic metabolism in humans.

ABSTRACT:

Background

In Bangladesh, > 50 million individuals are chronically exposed to inorganic arsenic (iAs) through drinking water, increasing risk for cancer and other iAs-related diseases. Previous studies show that individuals' ability to metabolize and eliminate iAs, and their risk of toxicity, is influenced by genetic variation in the AS3MT and FTCD gene regions.

Methods

To identify additional loci influencing arsenic metabolism, we used data from Bangladeshi individuals to conduct genome-wide association analyses of the relative abundances of arsenic species measured in both urine (n = 6,540) and blood (n = 976). These species include iAs, monomethylated arsenic (MMA) and dimethylated arsenic (DMA) species.

Results

In analyses of urine arsenic species, we identified a

SUBMITTER: Tamayo LI 

PROVIDER: S-EPMC12404487 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature