Improving immune-related health outcomes post-cesarean birth with a gut microbiome-based program: A randomized controlled trial.

ABSTRACT:

Background

Infants born via Cesarean section (C-section) often have a distinct gut microbiome and higher risks of atopic and immune-related conditions than vaginally delivered infants. We evaluated whether a microbiome-based program could shift gut microbiome composition and improve microbiome-associated health outcomes in C-section born infants.

Methods

This open-label, randomized, controlled trial included full-term C-section-born infants aged 0-3 months, randomized to an intervention (n = 25) or control arm (n = 29). Over 6 months, the intervention arm received two microbiome reports, personalized recommendations based on their microbiome, educational materials, and coaching calls focused on microbiome health. Parents reported health conditions via surveys.

Primary out

SUBMITTER: Nieto PA 

PROVIDER: S-EPMC12405607 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature