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Self-assembled DNA nanocarrier-enabled drug delivery for bone remodeling and antimicrobial applications.

ABSTRACT: We report a synthetic tetrahedral DNA nanocarrier (TDN) for treating bone defects and methicillin-resistant Staphylococcus aureus (MRSA) infection using in vitro studies. We successfully synthesized TDNs and demonstrated their excellent cytocompatibility with blood cells and immune cells. Zoledronic acid-loaded TDN displayed increased efficacy compared to free drugs in regulating bone remodeling, while vancomycin-loaded TDN showed an increased antibacterial effect against MRSA. In the future, this nano-drug delivery platform, with its multifunctional properties, can be potentially used to treat bone fractures and surgery-related MRSA infection.

SUBMITTER: Huang J 

PROVIDER: S-EPMC12408339 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature

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Self-assembled DNA nanocarrier-enabled drug delivery for bone remodeling and antimicrobial applications.

Huang Jiaqi J   Chakraborty Aishik A   Shamiya Yasmeen Y   Luo Wei W   Zahid Alap Ali AA   Paul Arghya A  

npj biomedical innovations 20250903 1

We report a synthetic tetrahedral DNA nanocarrier (TDN) for treating bone defects and methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) infection using in vitro studies. We successfully synthesized TDNs and demonstrated their excellent cytocompatibility with blood cells and immune cells. Zoledronic acid-loaded TDN displayed increased efficacy compared to free drugs in regulating bone remodeling, while vancomycin-loaded TDN showed an increased antibacterial effect against MRSA. In the fut  ...[more]

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