A low-cost point-of-care device for the simultaneous detection of two sexually transmitted bacterial pathogens in vaginal swab samples.

ABSTRACT: Curable sexually transmitted infections (STIs) caused by the bacteria Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) are widespread globally. These infections are particularly dangerous for female patients, causing pelvic inflammatory disease, infertility, and increased risk of HIV acquisition. Vaginal self-swab sampling can improve access to STI screening but is still subject to treatment delays due to centralized processing. A low-cost point-of-care (POC) device capable of detecting these bacteria from a self- or clinician-collected vaginal swab could address this delay and allow for more timely treatment. In this work, vaginal swab materials from patients infected with CT or NG required a filtration step before lysis and loop-mediated isothermal amplification (L

SUBMITTER: Heiniger EK 

PROVIDER: S-EPMC12412115 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature