Clonal hematopoiesis and risk of nonmyeloid subsequent malignant neoplasms after autologous hematopoietic cell transplantation.

ABSTRACT:

Background

The association between clonal hematopoiesis (CH) and nonmyeloid subsequent malignant neoplasms (SMNs) after autologous hematopoietic cell transplantation (HCT) has not been explored.

Methods

This was a retrospective cohort study of 1931 consecutive patients who underwent HCT between 2010 and 2016 at a single center. DNA from pre-HCT mobilized blood products was sequenced to identify CH variants (variant allele frequency [VAF] ≥2%). The primary outcome was 8-year(y) cumulative incidence of nonmyeloid SMNs. Multivariable regression analysis was used to evaluate the association between CH and nonmyeloid SMNs, as well as cause-specific mortality.

Results

Median age at HCT was 58.8 y (range = 18.4-78.1 y); 389 patients (20.1% of the cohort) had at least 1 CH va

SUBMITTER: Rhee JW 

PROVIDER: S-EPMC12415965 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature