Logic-Gated Release of a Dual Payload from a β-Lactam Mechanophore with a Rotaxane Actuator.

ABSTRACT: The force-controlled release of functional molecules has attracted interest due to its potential use in drug delivery and self-healing applications. Clever mechanochemical devices have been developed to that effect, but most are limited by the payload (type, number) they can deliver and their responsiveness to a single stimulus (force). However, the applications envisaged above require the precise delivery of a complex payload. In this context, a device able to release a diverse set of cargo molecules in response to a varied number of stimuli is desired. Here, we present a rotaxane-based device that can release a dual payload in response to two different stimuli: force and water. The first payload is released mechanically, while the release of the second cargo requires both force and water

SUBMITTER: Chen L 

PROVIDER: S-EPMC12416451 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature