Synthesis of 1,3,4,6-Tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose (Mannose Triflate) Precursor for the Production of [¹⁸F] FDG.

ABSTRACT:

Purpose of the study

1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose (mannose triflate), the precursor used for the synthesis of [¹⁸F] Fluorodeoxyglucose ([¹⁸F] FDG) is imported from a few commercial suppliers abroad. As part of self-reliance, a reliable synthesis and characterization of mannose triflate has been developed, details of which are reported in this paper.

Materials and methods

Synthesis of 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose (Mannose triflate) carried by Triflation of 1,3,4,6-Tetra-O-acetyl-β-D-mannopyranose with Tf2O-pyridine under argon atmosphere for 6 h. Synthesized mannose triflate is used for the production of [¹⁸F] FDG using siemens explora FDG-4-automated module.

SUBMITTER: Ali Muhammad KS 

PROVIDER: S-EPMC12416619 | biostudies-literature | 2025 May-Jun

REPOSITORIES: biostudies-literature