SIRT6 Is a Key Regulator of Pancreatic β-Cell Survival and Function During Aging.

ABSTRACT:

Article highlights

Pancreatic β-cell function declines with age, but the underlying mechanism is poorly understood. In this study, we attempted to address how to reverse β-cell aging. Our data showed that sirtuin 6 (SIRT6) overexpression can reduce age-associated DNA damage, cell death, and functional decline in β-cells. Our findings suggest that improving Sirt6 gene expression and function may slow down β-cell decline in older patients.

SUBMITTER: Park J 

PROVIDER: S-EPMC12419459 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature