Influence of SARS-CoV-2 infection before and during organogenesis on embryo implantation and development outcomes: A prospective cohort observational study.

ABSTRACT:

Background

Extensive research has demonstrated the detrimental effects of COVID-19 on maternal-fetal outcomes. However, few studies have examined the impact of SARS-CoV-2 infection before and during organogenesis on human embryo implantation and subsequent development. Additionally, the influence of SARS-CoV-2 on the endometrial microenvironment, which is critical for embryo implantation, remains poorly understood. This study seeks to address these gaps in knowledge.

Methods and findings

We prospectively enrolled 971 participants undergoing frozen-thawed embryo transfer (FET) during the final two months of 2022, coinciding with the nationwide COVID19 outbreak following the end of China's Zero-Covid policy. Patients undergoing FET during this period were at high risk of SARS-

SUBMITTER: Li Y 

PROVIDER: S-EPMC12425316 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature