TRPV2 Regulates Function of Human Neutrophil Granulocytes.

ABSTRACT: Neutrophils play a vital role in human immune defense, and their dysregulation can cause collateral damage in sepsis and autoimmune diseases. We provide evidence for the involvement of the transient receptor potential vanilloid 2 (TRPV2) in cytokine expression and transmigration in human neutrophils as well as in HL60 cells. These data identify TRPV2 as a candidate target for novel therapeutics regulating neutrophil activity.

SUBMITTER: Heinemann AS 

PROVIDER: S-EPMC12434796 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature