HLA-B*15:01-positive severe COVID-19 patients lack CD8⁺ T cell pools with highly expanded public clonotypes.

ABSTRACT: Understanding host factors driving asymptomatic versus severe disease outcomes is of key importance if we are to control emerging and re-emerging viral infections. HLA-B*15:01 has been associated with asymptomatic SARS-CoV-2 infection in nonhospitalized individuals of European ancestry, with protective immunity attributed to preexisting cross-reactive CD8⁺ T-cells directed against HLA-B*15:01-restricted Spike-derived S_919-927 peptide (B15/S₉₁₉⁺CD8⁺ T-cells). However, fundamental questions remained on the abundance and clonotypic nature of CD8⁺ T-cell responses in HLA-B*15:01-positive patients who succumbed to life-threatening COVID-19. Here, we analyzed B15/S₉₁₉⁺CD8⁺ T-cell responses in COVID

SUBMITTER: Rowntree LC 

PROVIDER: S-EPMC12435269 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature