Neonatal inflammation and its association with asthma and obesity in late childhood among individuals born extremely preterm.

ABSTRACT:

Background

Asthma and obesity are frequent outcomes among individuals born extremely preterm and are associated with decreased lifespan. Neonatal inflammation is associated with chronic neurodevelopmental disorders; however, it is less studied in association with other later childhood chronic disorders in this population.

Methods

Fourteen hospitals in 5 U.S. states enrolled 1506 infants born before 28 weeks of gestation in the Extremely Low Gestational Age Newborn cohort in 2004-2014. Neonatal blood spots were collected on postnatal days 1, 7, 14, 21, and 28, and used to measure 14 inflammation-related proteins. Associations were evaluated between high (top quartile) levels of proteins and two chronic health disorders at ages 10 and 15 years: physician-diagnosed asthma and o

SUBMITTER: Emmanuel C 

PROVIDER: S-EPMC12435514 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature