Pregnancy-Related Disease Outcomes in Women With Moderate to Severe Multiple Sclerosis Disability.

ABSTRACT:

Importance

Understanding the association between pregnancy and clinical outcomes in women with moderate to severe multiple sclerosis (MS) disability is crucial for guiding family planning and management strategies.

Objective

To assess peripregnancy relapse activity and disability progression in women with a preconception Expanded Disability Status Scale (EDSS) score of 3 or higher.

Design, setting, and participants

This multicenter retrospective cohort study used data from the MSBase Registry, with clinical observations spanning 1984 through 2024. Study cohorts included pregnant women with MS with a preconception EDSS score of 3 or higher (range: 3-10, with higher scores indicating more severe MS-related disability) and propensity score-matched nonpregnant women with

SUBMITTER: Shipley J 

PROVIDER: S-EPMC12439057 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature