Strength-Oriented Virtual Exercise Training Intervention in Children and Adolescents with Cystic Fibrosis Under CFTR Modulators (the FIQMODE Study): Study Protocol for a Randomized Controlled Trial.

ABSTRACT: Muscle health has not been thoroughly analyzed in pediatric cystic fibrosis (CF) under elexacaftor/tezacaftor/ivacaftor (ETI) therapy together with exercise interventions in randomized controlled trials (RCTs). The aim of this study will be to determine the effects of a virtual live exercise training intervention on muscle health and cardiorespiratory fitness (CRF) variables in a pediatric population with CF under ETI therapy. The 'FIQMODE' Study (FIQ for CF in Spanish, or fibrosis quística; MOD for modulator therapy; and E for exercise) is a two-arm RCT to evaluate the feasibility and efficacy of a novel exercise intervention to improve the muscle health and quality of life (QoL) of children and adolescents with CF under ETI pharmacological therapies. The exercise group will follow a 16-w

SUBMITTER: Pantoja-Arevalo L 

PROVIDER: S-EPMC12445441 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature