Reward network mechanism in anhedonia and depression.

ABSTRACT:

Background

Depression is one of the most burdensome mental disorders. Anhedonia, a core symptom of major depressive disorder (MDD), is characterized by abnormal resting-state reward network (RN). However, it is unclear whether anhedonia symptom and depressive episode share similar resting-state RN mechanism, as well as whether the RN mechanism is a state or trait-like marker of depression. This study aims to clarify the two points by recruitingboth current and remitted depression.

Methods

Using functional Magnetic Resonance Imaging (fMRI) scans, this study observed the resting-state RN function connectivity (with the seed of ventral striatum) in patients with remitted depression (RMD, n = 27) and current depression (n = 30) and 33 normal controls. The low-frequency fluctuati

SUBMITTER: Sun X 

PROVIDER: S-EPMC12445566 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature